DSPE-PEG-Biotin is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and a biotin. It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle while also providing an biotin group for binding to avidin or streptavidin. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the biotin group to non-covalently bind to targeting molecules including antibody, aptamer, protein, and peptide.

References: 1. Noninvasive ultrasound molecular imaging of the effect of statins on endothelial inflammatory phenotype in early atherosclerosis. PloS one 8.3 (2013): e58761 Text.

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