mPEG-aldehyde (propionaldehyde) reacts with amine and N-terminal of peptide and protein to form an imine containing a C=N double bond, which can be further reduced. PEG aldehyde or ketone derivatives can be used in reversible PEGylation through its reaction with hydrazine or hydrazide forming a hydrolytic acyl hydrozone linkage. PEG butyraldehyde may be offered through custom synthesis.

References: 1. The effect of the acid-sensitivity of 4-(N)-stearoyl gemcitabineloaded micelles on drug resistance caused by RRM1 overexpression, Biomaterials. 2013 March; 34(9): 2327–2339, Text.

2. Fluorinated block co-polymers. U.S. Patent No. 8,691,284. 8 Apr. 2014. Text

3. Biocompatible adhesive polymers.Biocompatible adhesive polymers. U.S. Patent No. 8,907,045. 9 Dec. 2014. Text

4.Mechanically tunable, human mesenchymal stem cell viable poly(ethylene glycol)–oxime hydrogels with invariant precursor composition, concentration, and stoichiometry, https://doi.org/10.1016/j.mtchem.2018.11.003

5.Mechanisms of activity loss for a multi-PEGylated protein by experiment and simulation, Materials Today Chemistry, 12, 2019, 121-131, doi: 10.1016/j.mtchem.2018.12.007

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