DSPE-PEG-COOH is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and a carboxylic acid. It is a useful self-assembling reagent to prepare PEGylated liposome or micelle while also providing a COOH group for conjugation with amine-containing molecules. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the acid group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.

References:

1. Anti prostate cancer using PEGylated bombesin containing, cabazitaxel loading nano-sized drug delivery system, Journal Drug Development and Industrial ,Volume 42, 2016 - Issue 12, Text.

Click here to view an expanded list of hundreds of publications citing Creative PEGWorks products.